No that's not true, it's safe.
But for sure you will face difficulties in communicating as very less people know Hindi and English. Many a times your Ola Uber will cancel your ride if you can't talk to them in tamil and won't be able to guide your route and location.
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Sometimes coolies too cheat you at MAS, for me once they asked for 1000 rs for carrying 2 trolly bags weighting less than 50 kg combined.
I have to pay as I was unaware of it.
Usually people won't bother for being north Indian and they usually tend to be away and mostly not mingle with you. But if you approach them they mostly they will guide you correctly. Just try to avoid Hindi and prefer English, situation worsens if you go interior TN away from city then even English won't help you.
This is from my 2 year studies at pondicherry.